Community Sciences and Health Outcomes (CSHO) Core is a centralized point of access that facilitates personalized and culturally sensitive cancer research at the population-, community-, and clinic-level in central Pennsylvania. The Core provides services that add value to the research of the Penn State Hershey Cancer Institute by allowing Cancer Institute investigators to focus upon the science of their study rather than technical and developmental activities such as preparing data for background sections of grant applications, managing participant data and sample collection, and building community trust. The Core collaborates with investigators to develop research proposals for extramural funding in cancer etiology, prevention, early detection, treatment, and survivorship. The Core participates in descriptive, analytic and interventional studies. While the Core can assist investigators at any stage of a study, investigators are encouraged to contact the Core while in the planning stages of a study so that Core expertise and resources can be strategically incorporated into study design, protocol development, and method selection. Though the Core operates through three primary centers, Core and staff interact extensively with one another.