NIH

The following text can be modified for use in the grant applications that require support from the Pen State Clinical and Translational Science Institute (CTSI). For additional information, contact ctsi@pennstatehealth.psu.eduĀ 

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SHORT VERSION: The Penn State Clinical and Translational Science Institute (CTSI) was established in 2011 with grant funding from the Clinical and Translational Science Award (CTSA) program in the National Institutes of Health (NIH). The CTSI serves as an independent but highly integrated academic engine for clinical and translational science. The overall goals of the CTSI are to catalyze interdisciplinary collaboration and novel approaches to predict, prevent and treat disease; to provide access to investigators across the University to resources that enhance and rigorously evaluate the impact of clinical and translational research; to train a new generation of health professionals and investigators; and to effectively share and disseminate data, discoveries and new knowledge with researchers, health practitioners, other institutions and the community at large. The CTSI’s key cores include: 1. Bioinformatics; 2. Biostatistics, Epidemiology and Research Design (BERD), 3. Community and Collaboration; 4. Translational Endeavors; 5. Research Methods; 6. Hub Research Capacity; 7. Network Capacity; 8. Institutional Career Development and 9. NRSA Training.

LONG VERSION: The Penn State Clinical and Translational Science Institute (CTSI) was established in 2011 with grant funding from the Clinical and Translational Science Award (CTSA) program in the National Institutes of Health (NIH). The CTSI serves as an independent but highly integrated academic engine for clinical and translational science. The overall goals of the CTSI are to catalyze interdisciplinary collaboration and novel approaches to predict, prevent and treat diseases; to provide access to investigators across the University to resources that enhance and rigorously evaluate the impact of clinical and translational research; to train a new generation of health professionals and investigators; and to effectively share and disseminate data, discoveries, and new knowledge with researchers, health practitioners, other institutions and the community at large. The CTSI is made up of nine key cores, which together advance clinical and translational science efforts across the university.

The Bioinformatics Core provides expertise and training for analyzing clinical and genomic data from all data acquisition platforms. Staff is available for consultation and to customize these tools and provide training. These services are provided though the various CTSI partner units at the Hershey and University Park campuses, including the the Clinical Informatics Research Core, Center for Quality Innovation, Research IT Group, Data Warehouse Group, Bioinformatics Core, Center for Statistical Genetics, and the Institute for Genomics, Proteomics, and Bioinformatics.

The Biostatistics, Epidemiology, and Research Design (BERD) CoreĀ provides statistical and epidemiological support to investigators on study design, data management, data entry, statistical software usage and analysis. If offers collaborations with researchers on grant proposals, and also provides education in statistical design and methods to investigators.

The Community and Collaboration Core provides core education and research services that enable investigators to design and conduct research protocols that effectively engage communities. The group provides consultation related to all phases of research when working with community partners.

The Translational Endeavors Core provides a comprehensive approach to continuous improvement in the translational workforce’s knowledge and skill sin rigorous, clinical research methodology, using an enterprise-wide systematic design and both on-site and online approaches for didactic instruction, continuing education, and experiential learning. It implements, adapts, and continuously refines the CTSI’s Translational Workforce Development and Pilot Translational and Clinical Studies programs. These programs train a translational workforce equipped with best practice skills, continuing education that disseminates high quality standards consistent with NCATS goals, and fosters innovative translational research that emphasizes team collaboration and advances in the science of translational science.

The Research Methods Core promotes excellence and efficiency in multidisciplinary research by providing high quality support in Biostatistics, Epidemiology and Research Design (BERD), Regulatory Knowledge and Research Ethics. The BERD Core is comprised of faculty and staff with expertise in study design, measurement, data management, data entry, statistical software usage, data analysis, and interpretation and reporting of results. The Regulatory Knowledge and Research Ethics Core promotes regulatory and ethical support, competency, and compliance for research.

The Hub Research Capacity Core facilitates clinical and translational research that involves participants from across the lifespan, including from underserved and underrepresented populations. The Hub Research Capacity provides support to ensure patient safety and the highest quality research protocols including tracking and modification to resource utilization to ensure project completion and translation of new knowledge into an impact on health.

The Network Capacity Core expedites the initiation and successful completion of multidisciplinary, translational health-related research studies, include multicenter trials at Penn State and across the CTSA network. The Network Capacity Core partners with NCATS, other CTSA hubs, and related national initiatives to disseminate and implement best practices for initiation and completion of studies, and for participant recruitment and retention. Consultation services are available for investigators on integration of trial recruitment efforts and study support.

The Institutional Career Development Core broadens the base of clinical and translational researchers by sponsoring multidisciplinary postdoctoral KL2 scholar program, a pre-doctoral professional and graduate student TL1 scholar program and a Short-term Intensive Translational Experience program for first year medical and graduate students. It also supports the dual-title Ph.D. and certificate programs in Clinical and Translational Science.

The NRSA Training Core supplements existing career diversity training and enables trainees to complete an internship in a translational research environment that is outside of their principal area of study.