Informatics for Integrating Biology and the Bedside (i2b2) helps clinical researchers use existing clinical data from Penn State Health for discovery research and, when combined with IRB-approved genomic data, facilitate the design of targeted therapies for individual patients with diseases having genetic origins.
It is widely used by the CTSA National Network and other academic health centers and industry, and is funded as a cooperative agreement with the National Institutes of Health. Learn more about i2b2 and the i2b2 Consortium here.
Obtaining an i2b2 Account
Penn State investigators wishing to use i2b2 must:
- Complete an introductory training (see times below under “Training”)
- Complete an IT Account Request Form with manager approval and sign a Data Use Agreement (email email@example.com for these forms)
Log in to i2b2 (internal access only; login required)
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Learn More About i2b2
Help with i2b2 is available virtually via Zoom through scheduled office hours. Appointments are not needed. Upcoming office hours are listed here; click on any event for details or to add it to your calendar.
Training is required to gain access to the i2b2 application.
Introductory training sessions are 90 minutes long and are offered twice a month virtually through Zoom. The Zoom link is provided upon registration.
Topics covered include:
- Intended use cases
- Strengths and limitations
- Demonstration of the application
- How to obtain additional data
Upcoming introductory trainings are listed here. Click on any event for details, to register, or to add it to your calendar.
The i2b2 team maintains several other training resources, including:
i2b2 uses International Classification of Diseases (ICD) codes, Logical Observation Identifiers Names and Codes (LOINC), and Current Procedural Terminology (CPT) codes in its searches.
The following links provide lookup tables for these codes:
- Vitals (Height, Weight, BMI, Systolic and Diastolic BP, Temperature, Heart Rate)
- Department Location
- Smoking Assessments
- ICD-o Code Set for Oncology
- Pulmonary Function Test (PFT)
- Problem Lists
Non-Discrete Data Not Available
- Notes (e.g., admission H and P, discharge summaries, clinic notes)
- Narrative Reports (e.g., radiology, surgical pathology, operative reports)
- Images (e.g., digital X-rays, EKGs, scanned documents)
- Microbiology Data (not yet recorded discretely in the EMR)
- Family History and Medical History (unless coded for billing purposes)
- Genomic Data