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TriNetX is similar to another Clinical and Translational Science Institute tool, Informatics for Integrating Biology and the Bedside, also known as i2b2. Both are searchable databases of more than 1.7 million Penn State Health patient observations dating back to 1997; however, TriNetX includes a more user-friendly graphical interface and dedicated customer service that can help with creating queries.

Why use TriNetX?

Through TriNetX and i2b2, users search for patients meeting specified criteria in a de-identified database, without prior Institutional Review Board (IRB) approval. Data are presented as unique patient counts, and a patient is counted only once. Data in TriNetX also exclude patients with only a medical record number or without diagnoses or codes. Such a search can help researchers determine whether enough potential patients are available to properly conduct a research study. With IRB approval and an enterprise information management request, patient-level data can be requested.

TriNetX also offers chart and graph options for data visualization and includes a rate-of-arrival algorithm. This algorithm determines how many patients matching certain criteria visited Penn State Health within the past three years, and then predicts how many potential visits will happen each quarter over the next year. A Trial Connect feature allows clinical research organizations and industry sponsors to determine and connect with potential study sites.

TriNetX is currently being used by nearly 30 of Penn State’s peers in the Clinical and Translational Science Award Program. It combines data with a global health research network, enabling health care organizations, pharmaceutical companies and contract research organizations to collaborate, enhance trial design, accelerate recruitment and bring new therapies to market faster.

Working with TriNetX

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