Skip to content


TriNetX is a web-based tool for research population cohort and feasibility queries that also enables researchers to collaborate with peers at other member institutions.

Why use TriNetX?

Through TriNetX and i2b2, users search for patients meeting specified criteria in a de-identified database, without prior Institutional Review Board (IRB) approval. Data are presented as unique patient counts, and a patient is counted only once. Data in TriNetX also exclude patients with only a medical record number or without diagnoses or codes. Such a search can help researchers determine whether enough potential patients are available to properly conduct a research study. With IRB approval and an enterprise information management request, patient-level data can be requested.

TriNetX also offers chart and graph options for data visualization and includes a rate-of-arrival algorithm. This algorithm determines how many patients matching certain criteria visited Penn State Health within the past three years, and then predicts how many potential visits will happen each quarter over the next year. A Trial Connect feature allows clinical research organizations and industry sponsors to determine and connect with potential study sites.

TriNetX is currently being used by nearly 30 of Penn State’s peers in the Clinical and Translational Science Award Program. It combines data with a global health research network, enabling health care organizations, pharmaceutical companies and contract research organizations to collaborate, enhance trial design, accelerate recruitment and bring new therapies to market faster.

Working with TriNetX

Request access, training and support for TriNetX and other research population tools

Jump to topic


Learn More

Code Lookups Expand answer

TriNetX uses International Classification of Diseases (ICD) codes, Logical Observation Identifiers Names and Codes (LOINC), and Current Procedural Terminology (CPT) codes in its searches.

The following links provide lookup tables for these codes:

Data Refresh Schedule Expand answer

The TriNetX tentative data refresh schedule is listed here. Please note that the application will be unavailable between 8 p.m. Tuesday and 5 p.m. Wednesday on the dates listed unless otherwise noted. Please see the change log section of this page for the current state of the data.

Standard Data Set Expand answer
Change Log Expand answer
Support Expand answer

For general technical help, or to report an issue with Clinical and Translational Science Institute applications including i2b2, call 833-577-4357 or email

For account help, go to Research Population Portal.

For help with queries, please complete a service request form.